Evaluation of Androgen Levels in Men
Androgens are thought to play a role in the pathogenesis of prostate cancer. We evaluated androgen levels in 3 age-matched groups of men who were part of the Baltimore Longitudinal Study of Aging: 1) 16 men with no prostatic disease by urologic history and exam (control group); 2) 20 men with a histologic diagnosis of benign prostatic hyperplasia (BPH) who had undergone simple prostatectomy; and 3) 20 men with a histologic diagnosis of prostate cancer (16 with local/regional cancer, and 4 with metastatic cancer). Luteinizing hormone (LH), total testosterone (T), and free T were measured on stored AM sera by radioimmunoassay (RIA).
Free T was also calculated from the measured concentrations of total T and sex hormone binding globulin (SHBG). The median number of repeated sex steroid measurements ranged from 6-9 over a period from 7-25 years prior to the diagnosis of prostate disease. There were no significant differences in age-adjusted LH, total T, SHBG, or calculated free T levels among the groups at 0-5, 5-10, and 10-15 years before diagnosis. These data suggest that there are no measurable differences in serum testosterone levels among men who are destined to develop prostate cancer and those without the disease.
In recent years, there has been increasing awareness about the role of androgens in men’s health. Androgens are a class of hormones that include testosterone, which is the primary male sex hormone. Low testosterone levels, also known as hypogonadism, can lead to a variety of symptoms such as fatigue, low libido, and decreased muscle mass.
Accurate evaluation of androgen levels is critical in order to properly diagnose hypogonadism and determine the best course of treatment. In some cases, testosterone replacement therapy (TRT) may be recommended to help raise testosterone levels and alleviate symptoms. However, it is important to note that not all men with low testosterone will benefit from TRT, and it is not recommended for certain populations such as men with prostate or breast cancer.
When considering TRT, it is crucial to obtain a thorough evaluation of androgen levels and assess any potential risks and benefits. This may involve measuring testosterone levels through a blood test, evaluating symptoms, and considering any underlying health conditions. By working closely with a healthcare provider, men can make an informed decision about whether TRT is right for them and take steps to maintain optimal androgen levels and overall health.